Isaac Clarke just can't seem to catch a break. Dead Space 2 starts off with Isaac realizing that he has some how been confined to a psych ward on a space station on Titan, one of Saturn's moons. Poor Isaac is suffering from a interesting case of dementia from exposing himself to the marker. To top everything off the entire station is on the grim end of a full on Necromorph out break. It is up to you to find out why you're here and above all else to survive.
In Dead Space 2 you will meet more characters and interact with the story on a more personal level. Also Isaac has a voice now! Not that Isaac says all too much but he says enough of what needs to be said that I feel more like I'm playing as a person instead of a punching bag with legs and a gun.